Title of article
A simple method for coupling aldehydes to solid support
Author/Authors
William A. Metz، نويسنده , , Winton D. Jones، نويسنده , , Fred L. Ciske، نويسنده , , Norton P. Peet، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
2399
To page
2402
Abstract
A new method for attaching aldehydes to solid supports has been developed employing a 2,2-bis(hydroxymethyl)propionic acid (DMPA®) functionalized resin. High loading levels are obtained for both aryl and alkyl aldehydes protected as their respective acetals. Treatment of the derivatized resin with 95% TFA then cleanly affords the recovered aldehyde in high yield.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789633
Link To Document