Title of article
Modulation of apoptosis in human lymphocytes by adenosine analogues
Author/Authors
Daniela Barbieri، نويسنده , , Claudio Franceschi، نويسنده , , Emidio Camaioni، نويسنده , , Stefano Costanzi، نويسنده , , Sauro Vittori، نويسنده , , Rosaria Volpini، نويسنده , , Gloria Cristalli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2533
To page
2538
Abstract
We previously described that 2-chloroadenosine (2CA) and 2-chloro-2′-deoxyadenosine (2CdA) induced apoptosis in human peripheral blood mononuclear cells (PBMC). In this study we tested different adenosine analogues on PBMC and we found that the modifications introduced in the 2CA structure prevented the molecule from exerting its apoptotic effect. On the other hand, substitutions on 2CdA are tolerated, although with a significant decrease in activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789659
Link To Document