Title of article
PD 176252 — The first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist
Author/Authors
V. Ashwood، نويسنده , , V. Brownhill، نويسنده , , M. Higginbottom، نويسنده , , D. C. Horwell، نويسنده , , J. Hughes، نويسنده , , R. A. Lewthwaite، نويسنده , , A. T. McKnight، نويسنده , , R. D. Pinnock، نويسنده , , M. C. Pritchard، نويسنده , , N. Suman-Chauhan، نويسنده , , C. Webb، نويسنده , , S. C. Williams، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2589
To page
2594
Abstract
In this paper we describe the development of a novel series of non-peptide, “balanced” neuromedin-B preferring (BB1)/gastrin-releasing peptide preferring (BB2) receptor ligands as exemplified by PD 176252. PD 176252, which exhibits nanomolar affinity for both the BB1 (Ki=0.15nM) and BB2 (Ki=1.0nM) receptors, has been demonstrated to be a competitive antagonist at these bombesin receptor subtypes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789670
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