Title of article
Biaryl acids: Novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2
Author/Authors
J. Milton، نويسنده , , M. J. Slater، نويسنده , , A. J. Bird، نويسنده , , D. Spinks، نويسنده , , G. Scott، نويسنده , , C. E. Price، نويسنده , , Leon S. Downing، نويسنده , , D. V. S. Green، نويسنده , , S. Madar، نويسنده , , R. Bethell، نويسنده , , D. K. Stammers، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2623
To page
2628
Abstract
A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with IC50s in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789676
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