Title of article
Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models
Author/Authors
Chenguang Wang، نويسنده , , Iain J. McFadyen، نويسنده , , John R. Traynor، نويسنده , , Henry I. Mosberg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
2685
To page
2688
Abstract
A pair of diastereomeric peptidomimetics based upon opioid receptor-binding pharmacophore models derived for a series of opioid tetrapeptides was synthesized. Both analogues display high opioid receptor affinity, moderate selectivity for the μ opioid receptor, and are potent, full agonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789687
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