Title of article
Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D
Author/Authors
Carolyn DiIanni Carroll، نويسنده , , Theodore O. Johnson، نويسنده , , Shewei Tao، نويسنده , , Giorgio Lauri، نويسنده , , Marc Orlowski، نويسنده , , Ilya Y. Gluzman، نويسنده , , Daniel E. Goldberg، نويسنده , , Roland E. Dolle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
3203
To page
3206
Abstract
A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P1′, P2–P4 surrogates. Evaluation of this encoded library against two aspartyl proteases, plasmepsin II and cathepsin D, led to the identification of selective inhibitors for each enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789787
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