Title of article
Synthesis of 5-substituted quinazolinone derivatives and their inhibitory activity in vitro
Author/Authors
Du-Jong Baek، نويسنده , , Yang-Kee Park، نويسنده , , Hong Il Heo، نويسنده , , Myounghee Lee، نويسنده , , Zungyoon Yang، نويسنده , , Myounghee Choi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
3287
To page
3290
Abstract
Quinazolinone derivatives I and their methyl esters were synthesized and evaluated as nonclassical lipophilic inhibitors of thymidylate synthase. Compounds Ib and Ic containing OH and CO2H as R substituents, respectively, were most effective, indicating that hydrogen bonding may contribute to the increased inhibitory activity. These compounds further showed high cytotoxic activity against tumor cells in culture.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789803
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