Title of article
Butyrophenone analogues in the carbazole series: Synthesis and determination of affinities at D2 and 5-HT2A receptors
Author/Authors
Christian F. Masaguer، نويسنده , , Emilio Formoso، نويسنده , , Enrique Ravi?a، نويسنده , , Helena Trist?n، نويسنده , , M. Isabel Loza، نويسنده , , Emilia Rivas، نويسنده , , JoséAngel Fontenla، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
3571
To page
3576
Abstract
We describe a practical and efficient route for synthesis of 2-aminomethyl-1,2,3,9-tetrahydro-4H-carbazol-4-ones using an effective Fisher indole methodology. The most active compounds, 4b (QF 2003B) and 4c (QF 2004B), with pKi (5-HT2A/D2) ratio of 1.28 show an antipsychotic profile according to Meltzerʹs classification.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789858
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