Title of article
Synthesis of 6(α,β)-aminocholestanols as ergosterol biosynthesis inhibitors
Author/Authors
Pierre Beuchet، نويسنده , , Laïla El kihel، نويسنده , , Michel Dherbomez، نويسنده , , Georges Charles، نويسنده , , Yves Letourneux، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
3627
To page
3630
Abstract
Δ7-5-Desaturase catalyses one of the last steps in ergosterol biosynthesis in fungi. Moreover Δ5-unsaturation is necessary for the sparking function. Synthesis of three pairs of C-6 epimeric cholestanol derivatives are described as potential growth inhibitors. Preliminary results suggest that 6β-aminocholestanol is a potent antifungal agent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789868
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