Title of article
Synthesis and biological evaluation of novel cryptophycin analogs with modification in the β-alanine region
Author/Authors
Chuan Shih، نويسنده , , Lynn S. Gossett، نويسنده , , Joseph M. Gruber، نويسنده , , C. Sue Grossman، نويسنده , , Sherri L. Andis، نويسنده , , Richard M. Schultz، نويسنده , , John F. Worzalla، نويسنده , , Tom H. Corbett، نويسنده , , James T. Metz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
69
To page
74
Abstract
Structure modification of the β-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (β-alanine) with various (1)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789895
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