Title of article
The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-D]pyrimidine based antifolates as antineoplastic and antiarthritic agents
Author/Authors
Lynn S. Gossett، نويسنده , , Lillian L. Habeck، نويسنده , , Katherine A. Shackelford، نويسنده , , Laurane G. Mendelsohn، نويسنده , , Susan B. Gates، نويسنده , , John F. Worzalla، نويسنده , , Tracy D. Self، نويسنده , , Karla S. Theobald، نويسنده , , Sherri L. Andis، نويسنده , , Richard M. Schultz، نويسنده , , Chuan Shih، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
75
To page
78
Abstract
A new series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates 1–3 were synthesized through an efficient conversion of 2-pivaloyl-4-oxo-6-ethynylpyrido[2,3-d]pyrimidine 5 to the corresponding 4-amino analog 7 via the activated 1,2,4-triazole intermediate 6. Compound 7 was used as the key intermediate for the preparation of the final products. The detailed biological evaluation of these compounds both as antineoplastic and antiarthritic agents will be discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789896
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