Title of article
Indolocarbazole poisons of human topoisomerase I: Regioisomeric analogues of ED-110
Author/Authors
David E. Zembower، نويسنده , , Heping Zhang، نويسنده , , Jayana P. Lineswala، نويسنده , , Mary J. Kuffel، نويسنده , , Shelley A. Aytes، نويسنده , , Matthew M. Ames، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
145
To page
150
Abstract
All four “symmetrical” regioisomers of ED-110, an indolocarbazole derivative having potent activity against human topoisomerase I (Topo I) were synthesized. The isomer containing hydroxyl groups in the 3- and 9-positions was approximately ten-fold more active against Topo I, and 5- to 35-fold more active against human solid tumor cell lines in vitro, relative to ED-110.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789910
Link To Document