Title of article
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis
Author/Authors
Meng-Hsin Chen، نويسنده , , Mark G. Steiner، نويسنده , , Stephen E. de Laszlo، نويسنده , , Arthur A. Patchett، نويسنده , , Matt S. Anderson، نويسنده , , Sheryl A. Hyland، نويسنده , , H. Russell Onishi، نويسنده , , Lynn L. Silyer، نويسنده , , Christian R. H. Raetz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
313
To page
318
Abstract
A series of carbohydroxamido-oxazolidine inhibitors of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, the enzyme responsible for the second step in lipid A biosynthesis, was identified. The most potent analog L-161,240 showed an IC50 = 30 nM in the DEACET assay and displayed an MIC of 1 3 μg/mL against wild-type E. coli.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789944
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