Title of article
On the relationship of OSW-1 to the cephalostatins
Author/Authors
Chuangxing Guo، نويسنده , , Thomas G. LaCour، نويسنده , , P. L. Fuchs، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
419
To page
424
Abstract
Antineoplastic bis-steroidal (cephalostatin-type) analogues of the saponin OSW-1 were produced from a dihydroaglycone of OSW-1. The key aglycone 6H was obtained from 5α-androstan-3β-ol-17-one in 8 steps (38% yield). The SAR of the aglycones, intermediates, and hybrid analogues provide insights regarding the proposed common role of C22-oxocarbenium ions in the bioactivity of both OSW-1 and cephalostatins
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789964
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