Title of article
High affinity retinoic acid receptor antagonists: Analogs of AGN 193109
Author/Authors
Alan T. Johnson، نويسنده , , Liming WANG، نويسنده , , Samuel J. Gillett، نويسنده , , Roshantha A. S. Chandraratna، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
573
To page
576
Abstract
A series of high affinity retinoic acid receptor (RAR) antagonists were prepared based upon the known antagonist AGN 193109 (2). Introduction of various phenyl groups revealed a preference for substitution at the para-position relative to the meta-site. Antagonists with the highest affinities for the RARs possessed hydrophobic groups, however, the presence of polar functionality was also well tolerated.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789995
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