Title of article
1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors
Author/Authors
J. B. M. Rewinkel، نويسنده , , H. Lucas، نويسنده , , P. J. M. van Galen، نويسنده , , A. B. J. Noach، نويسنده , , T. G. van Dinther، نويسنده , , A. M. M. Rood، نويسنده , , A. J. S. M. Jenneboer، نويسنده , , C. A. A. van Boeckel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
685
To page
690
Abstract
Replacement of the highly basic benzamidine moiety of NAPAP by the moderately basic 1-aminoisoquinoline moiety resulted in thrombin inhibitors with improved selectivity towards trypsin and enhanced Caco-2 cell permeability
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790018
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