Title of article
Antitumor agents 1871: Synthesis and cytotoxicity of substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds
Author/Authors
Zhengyu Yang، نويسنده , , Yi Xia، نويسنده , , Peng-Xia Liu، نويسنده , , Yoko Tachibana، نويسنده , , Kenneth F. Bastow، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
713
To page
716
Abstract
Several substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-ones and related compounds were synthesized and evaluated for their in vitro cytotoxicity against a panel of human tumor cell lines. The most active compound (3) showed significant cytotoxic activity with GI50 values in the micromolar range.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790023
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