Title of article
Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease
Author/Authors
Janet S. Plummer، نويسنده , , Cuiman Cai، نويسنده , , Sheryl J. Hays، نويسنده , , John L. Gilmore، نويسنده , , Mark R. Emmerling، نويسنده , , Walter Michael Halbmayer، نويسنده , , Lakshmi S. Narasimhan، نويسنده , , M. Desiree Watson، نويسنده , , Kevin Wang، نويسنده , , Rathna Nath، نويسنده , , Lori M. Evans، نويسنده , , Juan C. Jaen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
815
To page
820
Abstract
A series of 2-sulfonyl-4H-3,1-benzoxazinones was prepared that inhibit C1r protease in vitro. Several compounds were found to be selective for C1r verses the related serine protease trypsin. Selected compounds demonstrated functional activity in a hemolysis assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790043
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