Title of article
Novel reverse-turn mimics inhibit farnesyl transferase
Author/Authors
Ruiping Liu، نويسنده , , Dennis L. -Y. Dong، نويسنده , , Rosemarie Sherlock، نويسنده , , H. Peter Nestler، نويسنده , , Cesare Gennari، نويسنده , , Antonia Mielgo and، نويسنده , , Carlo Scolastici، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
847
To page
852
Abstract
Reverse-turn inducing bicyclic lactams were incorporated into the substrate sequence recognized by farnesyl transferase to create inhibitors of RAS farnesylation. While the free peptides did not show any effect on the farnesylation, their Fmoc-protected counterparts impede the transformation of RAS with IC50ʹs in the low micromolar range.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790049
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