Title of article
Investigation of the S3 site of thrombin: Design, synthesis and biological activity of 4-substituted 3-amino-2-pyridones incorporating P1-argininals
Author/Authors
John E. Reiner، نويسنده , , Margeurita S. Lim-Wilby، نويسنده , , Terence K. Brunck، نويسنده , , Theresa Ha-Uong، نويسنده , , Erick A. Goldman، نويسنده , , Matthew A. Abelman، نويسنده , , Ruth F. Nutt، نويسنده , , J. Edward Semple، نويسنده , , Susan Y. Tamura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
895
To page
900
Abstract
A novel scaffold for P4-P2 dipeptide mimics containing a rigid pyridone spacer was designed based on a virtual library strategy. Several selected nonpeptidic 4-aralkyl or 4-alkylpyridones incorporating a P1-argininal sequence were prepared. The modeling studies, synthesis and biological activities of these unique pyridone derivatives are reported herein.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790058
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