Title of article
Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs
Author/Authors
Donald J. P. Pinto، نويسنده , , Douglas G. Batt، نويسنده , , William J. Pitts، نويسنده , , Joseph J. Petraitis، نويسنده , , Michael J. Orwat، نويسنده , , Shuaige Wang، نويسنده , , James W. Jetter، نويسنده , , Susan R. Sherk، نويسنده , , Gregory C. Houghton، نويسنده , , Robert A. Copeland، نويسنده , , Maryanne B. Covington، نويسنده , , James M. Trzaskos، نويسنده , , Ronald L. Magolda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
919
To page
924
Abstract
The discovery of terphenyl derivatives as highly selective COX-2 inhibitors resulted from our efforts to overcome poor pharmacokinetics demonstrated by the COX-2 selective diarylthiophene DuP 697 [2-bromo-4-(4′-sulfonylmethyl)phenyl-5-(4′-fluoro)phenylthiophene]. Detailed SAR related to the ortho-biphenyls and variants of the central ring are described herein.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790062
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