Title of article
4-Phenylthiazole derivatives inhibit IL-6 secretion in osteoblastic cells and suppress bone weight loss in ovariectomized mice
Author/Authors
Kohji Yamaguchi، نويسنده , , Mika Yada، نويسنده , , Tomoko Tsuji، نويسنده , , Yuriko Hatanaka، نويسنده , , Ken-ichi Goda، نويسنده , , Takeo Kobori، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
957
To page
960
Abstract
A series of 4-phenylthiazole derivatives were synthesized and tested their inhibitory effect on the interleukin-6 secretion stimulated by PTH in osteoblastic cells. SCRC2941-18, 2-amino-4-(4-chlorophenyl)-5-methylthiazole, was found to be the most potent inhibitor in the derivatives. Furthermore, SCRC2941-18 significantly suppressed the bone weight loss in the ovariectomized mice, an osteoporosis model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790070
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