Title of article
Synthesis of caged peptides using caged lysine: Application to the synthesis of caged AIP, a highly specific inhibitor of calmodulin-dependent protein kinase II
Author/Authors
Yoshiro Tatsu، نويسنده , , Yasushi Shigeri، نويسنده , , Atsuhiko Ishida، نويسنده , , Isamu Kameshita، نويسنده , , Hitoshi Fujisawa، نويسنده , , Noboru Yumoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
1093
To page
1096
Abstract
Nα-Fmoc-N -(2-nitrobenzyloxycarbonyl)-lysine has been prepared and used in the solid-phase synthesis of caged peptides. The synthesized caged AIP (cagedKcagedKALRRQEAVDAL) showed characteristics required for caged peptides including a significantly reduced inhibitory activity to calmodulin-dependent protein kinase II and instantaneous recovery of the activity with photo-irradiation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790097
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