Title of article
Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics
Author/Authors
Maurice Petitou، نويسنده , , Pierre Alexandre Driguez، نويسنده , , Philippe Duchaussoy، نويسنده , , Jean-Pascal Hérault، نويسنده , , Jean-Claude Lormeau، نويسنده , , Jean-Marc Herbert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1161
To page
1166
Abstract
A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790111
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