Title of article
Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors
Author/Authors
Jeffery S. Carter، نويسنده , , D. J. Rogier، نويسنده , , Matthew J. Graneto، نويسنده , , Karen Seibert and، نويسنده , , Carol M. Koboldt، نويسنده , , Yan Zhang، نويسنده , , John J. Talley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
1167
To page
1170
Abstract
A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790112
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