Title of article
Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases
Author/Authors
Shinwa Kurihara، نويسنده , , Takeshi Tsumuraya، نويسنده , , Ikuo Fujii، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1179
To page
1184
Abstract
Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an inhibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for their ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790115
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