Title of article
Synthesis and evaluation of geldanamycin-estradiol hybrids
Author/Authors
Scott D. Kuduk، نويسنده , , Fuzhong F. Zheng، نويسنده , , Laura Sepp-Lorenzino، نويسنده , , Neal Rosen، نويسنده , , Samuel J. Danishefsky، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1233
To page
1238
Abstract
Geldanamycin (GDM) binds to the Hsp90 chaperone protein and causes the degradation of several important signalling proteins. A series of novel estradiol-geldanamycin hybrids has been synthesized and evaluated for their ability to induce the selective degradation of the estrogen receptor (ER). The hybrid compounds are active and more selective than the parent causing degradation of ER and HER2, but not other GDM targets.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790126
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