Title of article
Inhibition of human telomerase by PNA-cationic peptide conjugates
Author/Authors
Joseph G. Harrison، نويسنده , , Christelle Frier، نويسنده , , Ronald Laurant، نويسنده , , Regina Dennis، نويسنده , , Kevin D. Raney، نويسنده , , Shankar Balasubramanian، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1273
To page
1278
Abstract
The inhibition of human telomerase has been explored using peptide conjugated derivatives of a PNA pentamer directed at the RNA template of telomerase. It is demonstrated that the presence of cationic peptides at the N-terminus of the PNA results in enhanced inhibition of telomerase activity. Furthermore, inhibition depended on the specificity of PNA recognition.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790134
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