Title of article
Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists
Author/Authors
Bin Tao، نويسنده , , Tien L. Huang، نويسنده , , Terre A. Sharma، نويسنده , , Ian J. Reynolds، نويسنده , , Isaac O. Donkor، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1299
To page
1304
Abstract
A series of novel bisbenzamidines and bisbenzimidazolines with different linker connecting the aromatic groups was tested in vitro for NMDA receptor antagonist activity. IC50 values for these compounds ranged from 1.2 to>200 μM. The bisbenzamidine with a homopiperazine ring as the central linker was found to be the most potent NMDA receptor antagonist among all the pentamidine analogues tested so far.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790139
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