Title of article
Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis
Author/Authors
D. R. Barn، نويسنده , , A. Bom، نويسنده , , J. Cottney، نويسنده , , W. L. Caulfield، نويسنده , , J. R. Morphy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1329
To page
1334
Abstract
Two focused libraries of delta opioid ligands were synthesised using AlCl3 facilitated aminolysis. Several compounds were identified with DOR binding affinities higher or similar to SNC-80. A novel acyclic derivative of SNC-80 produced antinociception in the acetic acid abdominal constriction test, which is at least partially mediated via the δ-opioid receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790144
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