Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors

Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [η6-3-(dipropylamino)chroman]Cr(CO)3. Several of the compounds have high affinity for 5-HT1 receptors whereas the affinity for D2 receptors is lower, the 8-arylated derivatives being slightly more potent than the 8-aroylated analogues.