Title of article
A substrate combinatorial array for caspases
Author/Authors
Dennis Lee، نويسنده , , Jerry L. Adams، نويسنده , , Martin Brandt، نويسنده , , Walter E. DeWolf Jr.، نويسنده , , Paul M. Keller، نويسنده , , Mark A. Levy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1667
To page
1672
Abstract
An efficient strategy for the synthesis of a tetrapeptidyl substrate combinatorial array directed toward the caspases is described. Testing of this array with caspases 1 and 4 gave substrate hydrolytic profiles characteristic of each caspase, and permitted the identification of efficiently processed substrates. A comparison of this approach to that using a positional scanning library is presented.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790209
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