Title of article
1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties
Author/Authors
Alan P. Kozikowski، نويسنده , , Gian Luca Araldi، نويسنده , , Werner Tückmantel، نويسنده , , Sergey Pshenichkin، نويسنده , , Elena Surina، نويسنده , , Jarda T. Wroblewski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1721
To page
1726
Abstract
The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790220
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