Title of article
Synthesis and biological activity of anthelmintic thiadiazoles using an AF-2 receptor binding assay
Author/Authors
Byung H. Lee*، نويسنده , , Fred E. Dutton، نويسنده , , Michael F. Clothier، نويسنده , , Jerry W. Bowman، نويسنده , , John P. Davis، نويسنده , , Sandra S. Johnson، نويسنده , , Eileen M. Thomas، نويسنده , , Marjorie R. Zantello، نويسنده , , Erich W. Zinser، نويسنده , , James C. McGuire، نويسنده , , David P. Thompson، نويسنده , , Timothy G. Geary، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1727
To page
1732
Abstract
Following our discovery of the strong binding of thiadiazole 1 to the AF-2 neuropeptide receptor of gastrointestinal nematodes (e.g., Ascaris suum), we prepared two series of analogs. Only the series containing the thiadiazole ring had potencies comparable to that of compound 1. Analog 50 exhibited an apparent potency in the AF-2 binding assay 300 times that of compound 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790221
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