Title of article
Lipase-catalysed acylation of prostanoids
Author/Authors
Omar Parve، نويسنده , , Ivar J?rving، نويسنده , , Ivar Martin، نويسنده , , Andrus Metsala، نويسنده , , Imre Vallikivi، نويسنده , , Madis Aidnik، نويسنده , , T?nis Pehk، نويسنده , , Nigulas Samel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1853
To page
1858
Abstract
Natural prostaglandins (PG) F2α and E1 as well as (+)-cloprostenol were regioselectively 11-acylated using Novozym® 435 as a catalyst and vinyl acetate as an acyl donor. Unlike the above compounds the 15-OH group of PGE2 was also acylated with a significant velocity under the same conditions. The enantiospecificity of the lipase-catalysed 11-acetylation of cloprostenol was established by separate treatment of (+)- and (−)-cloprostenols.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790244
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