Title of article
The synthesis of water soluble prodrugs analogs of echinocandin B
Author/Authors
Michael J. Rodriguez، نويسنده , , Vasu Vasudevan، نويسنده , , James A. Jamison، نويسنده , , Peter S. Borromeo، نويسنده , , William W. Turner، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1863
To page
1868
Abstract
A facile synthesis of phosphonate and phosphate ester prodrugs on the phenolic hydroxy of two echinocandin semisynthetic derivatives is reported. The water solubility and stability profiles of the ECB compounds varied with the choice of alkyl group used. In some cases, the ester prodrugs with small aliphatic side chains retained antifungal activity while enhancing water solubility.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790246
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