Title of article
Structure-based design of a non-peptidic antagonist of the SH2 domain of GRB2
Author/Authors
Giorgio Caravatti، نويسنده , , Joseph Rahuel، نويسنده , , Brigitte Gay، نويسنده , , Pascal Furet، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1973
To page
1978
Abstract
The structure-based design and synthesis of a completely non-peptidic, micromolar antagonist of the SH2 domain of Grb2 is presented. The compound mimics the two main pharmacophores of the natural ligand, the phenylphosphate of the phosphotyrosine residue and the β-carboxamide of the X+2 asparagine, which are linked by a rigid aromatic spacer.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790268
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