Title of article
4-Hydroxy-5,6-Dihydro-2H-pyran-2-ones. 3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1′ and S2′ of the HIV-1 protease enzyme
Author/Authors
Edmund L. Ellsworth، نويسنده , , John Domagala، نويسنده , , J. V. N. Vara Prasad، نويسنده , , Susan Hagen، نويسنده , , Donna Ferguson، نويسنده , , Tod Holler، نويسنده , , Donald Hupe، نويسنده , , Neil Graham، نويسنده , , Caroline Nouhan، نويسنده , , Peter J. Tummino، نويسنده , , Greg Zeikus، نويسنده , , Elizabeth A. Lunney، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2019
To page
2024
Abstract
5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S1, S2, S1′, and S2′ pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position heterocyclic scaffolds that bind to the S1′ and S2′ pockets have provided a number of selected analogs that display high HIV-1 protease inhibitory activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790276
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