Title of article
Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129
Author/Authors
Morihiro Mitsuya، نويسنده , , Kumiko Kawakami، نويسنده , , Yoshio Ogino، نويسنده , , Keiko Miura، نويسنده , , Toshiaki Mase، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
2
From page
2037
To page
2038
Abstract
A diastereoselective synthesis of J-104129 (1) was developed. A key step of this synthesis was Michael addition of enolate generated from cis-chiral dioxolane 2 to cyclopentenone, followed by hydrogenolysis of the resultant enol triflate 4. A mixture of cyclopentyldioxolane (5, 6) was hydrolyzed with sodium hydroxide to yield carboxylic acid 7 in 86% ee.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790279
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