Title of article
Polyunsaturated fatty acid anilides as inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT)
Author/Authors
Naoto Matsuyama، نويسنده , , Tetsuya Kosaka، نويسنده , , Mina Fukuhara، نويسنده , , Yasuji Soda، نويسنده , , Koji Mizuno، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2039
To page
2042
Abstract
A series of polyunsaturated fatty acid anilides were synthesized and evaluated as ACAT inhibitors. Compound 24 had potent inhibitory activity against microsomal ACAT derived from U937, HepG2 and Caco-2 cell lines. Therefore, it might be expected to act as an antiarteriosclerotic and hypocholesterolemic agent. Interestingly, the ACAT inhibitory potency of 24 varied significantly depending on the source of the enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790280
Link To Document