Title of article
Synthesis and biological evaluation of analogs of the marine toxin polycavernoside A
Author/Authors
Louis Barriault، نويسنده , , Serge L. Boulet، نويسنده , , Kenshu Fujiwara، نويسنده , , Akio Murai، نويسنده , , Leo A. Paquette، نويسنده , , Mari Yotsu-Yamashita، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2069
To page
2072
Abstract
Second generation analogs of polycavernoside A (2) possessing a side chain at C-15 different from that of the natural toxin have been synthesized. The in vivo toxicities of these new compounds (expressed as the minimal lethal dose) have been evaluated in mice (ip) and compared to 2, its aglycone (8), and polycavernoside B (9). The bioactivity profile of enynene 5 is particularly notable.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790286
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