Title of article
C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study
Author/Authors
Mark T. Goulet، نويسنده , , Peter J. Sinclair، نويسنده , , Frederick Wong، نويسنده , , Mary Jo Staruch، نويسنده , , Francis J. Dumont، نويسنده , , John G. Cryan، نويسنده , , Gregory J. Wiederrecht، نويسنده , , Matthew J. Wyvratt Jr.، نويسنده , , William H. Parsons، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2085
To page
2088
Abstract
A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity. Oxygen-bearing substituents along the 2-carbon tether can further increase the potency of this design.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790289
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