Title of article
On-resin macrocyclization of peptides via intramolecular S Ar reactions
Author/Authors
Christopher Fotsch، نويسنده , , G. Kumaravel، نويسنده , , Sushil K. Sharma، نويسنده , , Arthur D. Wu، نويسنده , , John S. Gounarides، نويسنده , , N. R. Nirmala، نويسنده , , Russell C. Petter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2125
To page
2130
Abstract
On-resin macrocyclization via an S Ar reaction is employed in the synthesis of tocinoic acid analogs. Specifically, an N-terminal nitrofluorobenzene is attacked by a nucleophilic C-terminal sidechain. The remaining nitro group can be reduced and acylated. NMR is used to compare the conformation of the new macrocyclic peptides to tocinoic acid.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790297
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