Title of article
Derivatives of (R)-2-amino-5-methoxytetralin: Antagonists and inverse agonists at the dopamine D2 receptor
Author/Authors
Berit Backlund H??k، نويسنده , , Cecilia Brege، نويسنده , , Tero Linnanen، نويسنده , , ?sa Mikaels، نويسنده , , ?sa Malmberg، نويسنده , , Anette M. Johansson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2167
To page
2172
Abstract
A series of N-arylmethyl substituted (R)-5-methoxy-2-(propylamino)tetralins has been prepared and evaluated for affinity and efficacy at dopamine (DA) D2 receptors. The novel compounds appeared to be antagonists or inverse agonists. (R)-2-[(Benzyl)propylamino]-5-methoxytetralin (7) was characterized as a potent inverse agonists at DA D2 receptors in a [35S]GTPγS binding assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790305
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