Title of article
Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK)
Author/Authors
Thomas D. Aicher، نويسنده , , Robert E. Damon، نويسنده , , Judit Koletar، نويسنده , , Christine C. Vinluan، نويسنده , , Leonard J. Brand، نويسنده , , Jiaping Gao، نويسنده , , Suraj S. Shetty، نويسنده , , Emma L. Kaplan، نويسنده , , William R. Mann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2223
To page
2228
Abstract
Several oximes of triterpenes with a 17-β hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse after a single oral dose of 100 μmol/kg. However, the mechanism of the blood glucose lowering effect is likely unrelated to PDK inhibition.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790315
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