Synthesis and biological evaluation of novel 1β-methylcarbapenems having a new moiety at C-2

The synthesis and biological activity of the novel series of 1β-methylcarbapenems 1a-f, bearing a variety of 3″, 4″-disubstituted pyrrolidinamides as substituents at C-2, are described. Of these carbapenems, diol 1a shhowed the most potent and well balanced antibacterial activity against Gram-positive and Gram-negative. 1a was also evaluated for pharmacokinetics and in vivo therapeutic efficacy in systemic infections.