Title of article
Molecular structure of FR901277, a novel inhibitor of human leukocyte elastase, and its binding mode simulation
Author/Authors
Isao Nakanishi، نويسنده , , Takayoshi Kinoshita، نويسنده , , Toshiji Tada، نويسنده , , Takashi Fujita، نويسنده , , Hiroshi Hatanaka، نويسنده , , Akihiro Sato، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2397
To page
2402
Abstract
X-ray crystal structure analysis of FR901277, a novel inhibitor of human leukocyte elastase, was performed and revealed that the lipophilic side chains are located towards the outside of the molecule. Binding simulation using computational methods showed that these lipophilic moieties could bind to the hydrophobic binding pockets of HLE.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790349
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