Title of article
Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers
Author/Authors
Robert M. Schelkun، نويسنده , , Po-Wai Yuen، نويسنده , , Thomas C. Malone، نويسنده , , David M. Rock، نويسنده , , Sally Stoehr، نويسنده , , Balazs Szoke، نويسنده , , Katalin Tarczy-Hornoch، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2447
To page
2452
Abstract
Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for N-type VACCʹs over sodium and potassium channels. The methods of synthesis and preliminary pharmacology are discussed herein.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790358
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