Title of article
Fluorobenzamidrazone thrombin inhibitors: Influence of fluorine on enhancing oral absorption
Author/Authors
Koo Lee، نويسنده , , Won-Hyuk Jung، نويسنده , , Sang Yeul Hwang، نويسنده , , Sung-Hack Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2483
To page
2486
Abstract
LB30057 (1) is a selective and efficacious oral thrombin inhibitor. Fluorine-substitution on the phenylene ring of the benzamidrazone portion in both compound 1 and its derivatives gave, in many cases, enhanced oral absorption in rats while maintaining the intrinsic potency and selectivity. Compound 2 demonstrated a 3-fold increase in absorption.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790364
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