Title of article
Acylcarnitine analogues as topical, microbicidal spermicides.
Author/Authors
Prashant S. Savle، نويسنده , , Gustavo F. Doncel، نويسنده , , Stephen D. Bryant، نويسنده , , M. Patricia Hubieki، نويسنده , , R. Graham Robinette، نويسنده , , Richard D. Gandour، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2545
To page
2548
Abstract
Acylcarnitine analogues, (+)-6-Carboxylatomethyl-2-alkyl-4,4-dimethylmorpholinium (Z-n, where n = the number of carbons in the alkyl chain), synthesized in multi-gram quantities show in vitro activities as spermicides, anti-HIV agents, and inhibitors of the growth of Candida albicans. Activity improves with increasing chain length. Compound Z-15 is a candidate for further study as a topical, microbicidal spermicide.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790375
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